Automated Visual Inspection

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Inspection is a critical requirement for pharmaceutical products, mandated by regulations to ensure patient safety and product quality. Automated inspection plays a key role in optimizing the production process and maintaining consistency. We offer innovative and highly accurate automated technologies to detect cosmetic defects and visible particles in your products, whether they are filled with liquids, suspensions, or lyophilizates in syringes, vials, cartridges, or ampoules. With our extensive expertise in automated inspection, we deliver the most suitable camera and illumination technologies for your products.

The AIM2|5 series brings cutting-edge inspection to a proven platform. Designed for high-speed performance, it inspects up to 400 containers per minute with precision, ensuring reliable detection of particulate matter and cosmetic defects. Optionally, the system can be equipped with HVLD moduls or HSA sensors for leak testing.

Engineered for versatility, it accommodates a wide range of container types (ampoules, cartridges, vials, syringes) and products (clear water like solutions, emulsions, viscous , freeze-dried or oily products).

The key benefits are:

Advanced particulate inspection: SD technology, area cameras, and line scan cameras, with customized lighting and angles for precision.
Container flexibility: Inspects various container formats.
Supporting software: Precise detection and regression software
with offline recipe creation and optimization.
Enhanced inspection accuracy: Optional pre-spin turret to eliminate air bubbles and homogenize products.
Automated handling: Can be seamlessly integrated with De-/Renester solution for enhanced automation.

Designed for maximum adaptability, the facelifted AIM8+ series offers exceptional flexibility and easy customization to meet complex inspection needs. It ensures precise detection of particulate and cosmetic defects and can optionally integrate AI for enhanced accuracy. Operating at speeds up to 450 containers per minute, it delivers reliable results even for challenging products.

Engineered for diverse applications, it accommodates vials and is designed to inspect a wide range of products (clear water like solutions, emulsions, viscous , freeze-dried or oily products).

The key benefits are:

Advanced particulate inspection: SD technology, area cameras, and line scan cameras, with customized lighting and angles for precision.
Container flexibility: Inspects various container formats.
Smart reinspection: Built-in reinspection boosts efficiency and simplifies operations.
Supporting software: Precise detection and regression software
for offline recipe creation and optimization.
Enhanced inspection accuracy: Optional pre-spin turret to eliminate air bubbles and ensure homogenization.

Designed for full integration, our inspection line streamlines de-nesting, inspection, and re-nesting of pre-filled syringe nests. Ensuring gentle and precise handling, it prevents glass-to-glass contact throughout the process, safeguarding product integrity.

Engineered for syringes in nests, delivering safe and efficient processing every step of the way.

The key benefits are:

Damage and contamination prevention: Non-glass-to-glass contact during de-nesting, inspection, and re-nesting, safeguarding containers from damage and contamination.
Full nests only: Automatically fills gaps left by rejected containers for consistent, complete nests.
Operator-free operation: The integrated 6-axis robot automates de-nesting - gripping, eliminating manual handling, making it ideal for sterile RTU nest handling.
Modular flexibility: Functions as a de-nester, re-nester, or combined solution for varied needs.
Quick format changeover: Switch formats in less than 30 minutes.
Optimized transport: Vibration-free movement prevents bubbling, reducing false rejects.

Cracks and leaks in parenterals can compromise both sterility and efficacy. While small cracks or pinholes are undetectable by cameras or the naked eye, High Voltage Leak Detection (HVLD) reliably identifies them.

Our HVLD modules provide enhanced inspection for syringes, ampoules, and vials, ensuring product safety and effectiveness without compromising production efficiency.

The key benefits are:

Seamless integration: Integrate CCIT into a single system, optimizing space and simplifying operations.
Regulatory compliance: Fully compliant with the latest industry standards, including EU GMP Annex 1 and USP <1207>.
Enhanced safety: Identify leaks undetectable by conventional cameras or the human eye.
High throughput efficiency: Fast testing process ensures quick operation.
Reliable detection in low fill volumes: 360-degree leak detection identifies leaks undetectable by conventional methods, ensuring consistent results.
Effortless recipe creation and monitoring: Easy adjustments and precise tracking through individual data recording.

Headspace Analysis (HSA) ensures optimal testing of the integrity of containers with lyophilized products and sensitive liquids filled under vacuum or nitrogen atmosphere. By monitoring oxygen concentration or water pressure, HSA identifies both permanent and temporary leaks, preserving product sterility and efficacy.

Our integrated HSA sensor enhances inspection for ampoules and vials, ensuring product safety and effectiveness without compromising speed.

The key benefits are:

Seamless integration: Integrate CCIT into a single system, optimizing space and simplifying operations.
Regulatory compliance: Fully compliant with the latest industry standards, including EU GMP Annex 1 and USP <1207>.
Enhanced safety: Identify temporary and permanent leaks undetectable by conventional cameras or the human eye.
High throughput efficiency: Fast testing process ensures quick operation.
Retrofittable: Easily integrates into existing machines for seamless upgrades without the need for new equipment.

Key benefits

Product safety

Our innovative and highly accurate inspection platforms ensure product quality by reliably detecting cosmetic defects and particles

Improve production processes

The generation of analytical data supports you in gaining process knowledge and improving your processes

Combine visual and CCI inspection

We offer machine platforms that combine visual inspection and Container Closure Integrity Testing (CCIT) on a small footprint

Seamless Inspection and Handling of Pre-Filled Syringes with an integrated De-/Renester

Pre-inspection station for pre-sorting of gross defects

GMP Ready: Integrate visual inspection and leak detection for ampoules, vials, and syringes.

automated-visual-inspection-syringe-fill-edited

Featuring our patented Bubble Mask Tool, designed to distinguish bubbles from particles in all liquids, including viscous solutions.

automated-visual-inspection-for-ampoules

Optimize recipe adjustments offline and investigate defects without production disruption using our regression software.

Elimination of bubbles and product homogenization with our pre-spin table

Reliable and easy to validate

Our patented SD solution detects moving particles inside containers without rejecting surface flaws, ensuring consistent and accurate performance every time.

Intelligent inspection with AI – we offer automated inspection powered by deep learning

Use cases

DIR: Fully integrated syringe inspection line without glass-to-glass contact:

A holistic solution for the de-nesting, inspection and re-nesting of pre-filled syringes.

YT-AIM-2000C-video-inspection-cartridges-vials

AIM2023C: Automated inspection machine for cartridges

Inspection and labeling avaiblable for cartridges, vials, syringes and ampoules.

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Digital Solutions

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Parts

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Maintenance

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Technical Support

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Modernizations

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Training

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About us

We have installed over 1,500 inspection machines in the market. To reach this milestone, our experts have been contributing their experience and skills to numerous developments. And they have been supporting just as many customers in making their pharmaceuticals as safe as possible with manual, semi-automated and fully automated inspection equipment.

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years of experience

patents and patent applications

machines installed world-wide

locations

Our expertise, your advantage

Customers from around the globe rely on our expertise in visual inspection

We have supported some of the most renowned industry players in boosting their efficiency, expanding operations or upgrading their equipment to meet latest manufacturing standards. Explore our customer cases to find out more about the many areas of application.

Our expertise, your advantage

“We were able to systematically identify and adapt crucial sections within our filling and sealing processes, to make them more stable and reduce the number of unnecessary rejects even further. In fact, our performance is increasing from week to week.”
- Philippe Truelle, CEO of CDM Lavoisier

CDM Lavoisier decided to change their inspection processes for no less than 30 products in four different packaging formats. They are now all inspected on the AIM 3000 from Syntegon.

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Our expertise, your advantage

“This challenging project required a lot of dedication and expertise. In cooperation with Syntegon, we have implemented the world-first syringe inspection machine with AI and underline our market position, both in biotechnology production and in technology.”
- Manuel Soto, Principal Process Development Engineer at Amgen

Amgen, one of the world’s leading biotechnology companies, uses our AI-equipped inspection machine to reliably distinguish air bubbles at the syringe’s rubber stopper from foreign particles.

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Learn more about visual inspection

Intelligent inspection with AI

Automated inspection machines powered by deep learning

Crucial machinery for insulin manufacturers

High quality insulin for everyone

Inspection of milky products

We make visible, what the eye cannot see

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