The fight against diabetes and obesity

The new, cost-efficient SVP Essential is a fully automated, ready-to-use system to produce simple parenterals such as analgesics, insulin, and generic drugs.

reduce contamination risks and friction inside the cartridge. Syntegon’s portfolio of compact pharmaceutical cleaning systems for the low, medium and high output ranges prevents potentially harmful substances from compromising operator and patient safety. The integrated application of silicone layers allows easy stopper motion in pens.

Cleaned and siliconized cartridges are heated to 300 degrees Celisus to eliminate any contaminants. Syntegon offers versatile sterilization solutions for an effective treatment of porous loads and liquids in open, semi-sealed, or closed containers.

Following separation, cartridges are first stoppered from below. For suspensions, a glass or stainless-steel ball is added from above. Filling then takes place in several steps. Syntegon offers a wide range of technologies, including valve piston and peristaltic pump for highly customizable operations.  Filled cartridges are sealed with an aluminum cap. It includes a septum which is pierced by the needle during use. The aluminum cap is crimped and the cartridge is transported in Akylux boxes.

Syntegon has established a comprehensive portfolio, including open RABS, closed RABS, containment and isolator systems.

State-of-the-art technologies for visual inspection and container closure integrity testing (CCIT), including high voltage leak detection (HVLD), static division (SD), and headspace analysis (HSA).

Our modular assembly systems with scalable levels of automation reliably support the production of standard 4-piece disposable pens and come in different designs according to your desired production rates.

Tubs with syringe nests are packed in either single or double bags. They are loaded into automatic tub and bag opening (ATO/ABO) equipment, where the bags and the tubs’ Tyvek film and top layer are removed. The tubs are then transferred into the filling machine.

In the filling machine, the nests are removed from the tubs to fill and seal the syringes inside the nest. Semaglutides require small filling volumes (e. g., 1.5 ml within a 3 ml cartridge). Products are typically filled in rows in several steps to ensure high filling accuracy. Stoppering is based on vacuum technology for added precision.

Extensive processes call for thorough sterilization to eliminate any contamination in the filled and sealed product. Besides isolator technology, sterilization systems ensure highest product safety: syringes in tubs are sterilized at 121 degrees Celsius applying methods that are gentle on both the packaging and the medicines.

Safe syringes require a 100% inspection of all objects. Fully automated and highly flexible systems cover visual inspection and leak detection on a single platform, checking containers for cosmetic defects, intrinsic and extrinsic contamination, and leaking closures. Built-in de-nesting and re-nesting features make sure the syringes are handled gently during the process.

Flexible assembly platforms make sure that key auto-injector components like syringes, base caps, springs, and actuators are reliably assembled with fast and tool-free changeovers whenever production involves different formats. Various assembly methods (manual, semi-automated, fully automated) enable scalable processes. 

The new, cost-efficient SVP Essential is a fully automated, ready-to-use system to produce simple parenterals such as analgesics, insulin, and generic drugs.