Pharmaceutical Isolator | Safe Aseptic Filling

Integrated air management

Our integrated air management simplifies processes, reducing costs and increasing efficiency. One of the benefits is a significant reduction in the required space on the technical floor. This results in a more optimized workspace and efficient resource allocation. In addition, our integrated air management solution eliminates the need for external interfaces to the building, reducing complexity and increasing security.

Key benefits

Integrated systems

Filling machines, barrier technologies and peripheral equipment are seamlessly connected.

Safe aseptic filling

Maximum security trough monitored gloves, transfer ports and material locks.

Full lifecycle support

Syntegon’s expertise covers consulting, isolator design, installation and validation.

Features of our pharmaceutical isolators & barrier systems

Our barrier systems include open RABS, closed RABS, isolators, and containment systems. They all offer you maximum flexibility for a broad range of applications, protecting products and personnel in the best possible way. While our RABS enhance the quality of everyday multi-product manufacturing in existing cleanrooms, our isolators further boost the safety of filling lines for high potent medications.

Benefits:

Safe filling of aspectic, BSL and highly potent products
Qualification and validation support including cycle development
Intensive research for RABS, isolator and related barrier technologies

Isolators and production equipment form complex systems that need to function reliably. We focus on each component to make sure it seamlessly interacts with each other: safe interfaces between filling machines, isolators and subsequent systems, e.g., freeze-dryers or capping machines are a top priority. We not only combine machines from a single source; we also take care of the entire implementation, from concept planning to the installation of your isolator project.

Benefits:

Isolator, bio-decontamination and air-handling from a single source
Common integrated start-up (integrated FAT) of your entire line
Optimization of critical processing areas of filling machine and isolator

High potent products require utmost protection, and so does your staff. By effectively separating production areas and personnel, our barrier systems contribute to maintaining the highest hygiene and safety standards. Syntegon’s isolators combine a unique design with industry-leading technology, from air management to decontamination and peripheral systems, such as airlocks, transfer and testing equipment.

Benefits:

Special isolator design and pressure concepts for applications up to OEB 6
Fast, reproducible and fully validated decontamination processes, using Syntegon’s SafeVAP bio-decontamination system
Dedicated filter systems for potent applications

pharmaceutical-isolator-with-maximum-security

Our integrated air management simplifies processes, reduces costs and increases efficiency. The integrated air handling system minimizes the need for interfaces to the building and eliminates installations in the technical floor. This results in reduction of needed space and efficient resource allocation. Furthermore, it is compatible with most machine types.

Benefits:

Major reduction of needed space on technical floor and no interface to outside of building
Reduction of interface clarification to onsite works
Room in / room out concept for stable climate conditions (no outside influences)

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All from one source

All pieces of an isolator filling line are manufactured and assembled at the same site.

If you want to know more about isolators and the advantages of an integrated approach, watch the video.

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Shortest biodecontamination cycle times

Fastest biodecontamination cycle times in the industry:

Less than 60 minutes for a fully loaded production size isolator.
Shorter cycle times mean more time in production.

Let us be your partner in barrier technology, getting you to highest equipment utilization.

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Integrated air handling technology

Do you need a higher speed and higher output aseptic filler?

Syntegon also offers air handling systems fully integrated into the plenum of our largest isolators, to make users lives easier.

Get answers to all your questions about integrated air management.

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Key benefits

Explore the unique features that make Syntegon's isolator filling lines so special.

Integration of a comprehensive Factory Acceptance Test (FAT) for your entire production line.
Minimized complexity of interfaces.

Use case scenarios

Glove testing systems

The highest safety for isolators and RABS

Maintaining an aseptic production

How to transfer products into barrier systems

A challenge for sterile manufacturing

How will Annex 1 change fill/finish processes?

Syntegon and AbbVie

Taking ADC processing to the next level

RABS vs. Isolator

Choosing the right isolation technology

Fill/finish of liquid pharmaceuticals

Syntegon expands local support for import projects in North America

Aseptic and highly potent drugs

Insights into state-of-the-art sterile fill/finish applications

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Get in touch with us.

Service Agreements

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Digital Solutions

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Parts

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Maintenance

Find out more about Maintenance here.

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Technical Support

Find out more about Technical Support here.

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Modernizations

Find out more about Modernizations here.

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Training

Find out more about our Training here.

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Expert Services

Find out more about our Expert Services here.

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Isolator experts before it was fashion

Long-standing experience: We have been designing, developing and manufacturing reliable isolators for decades. Syntegon is your partner, offering valuable support across the entire lifecycle of your barrier system project.

Seamless systems: We integrate isolators, filling machines, decontamination equipment and HVAC technology to secure highly efficient, safe processes for your aseptic processing requirements.

Process efficiency: Syntegon isolators can be used in a wide variety of settings, thanks to their highly flexible set-ups. Your benefits: high product availability, improved filling quality and reduced operating costs.

Keep human intervention to the minimum – this is the mantra in pharmaceutical production. We know exactly how to combine good operator experience with the highest safety standards. Our industry-proven barrier systems and isolator technology from a single source allow to achieve the desired separation of production and personnel in the most varied manufacturing scenarios.

years of experience

patents and patent applications

machines installed world-wide

locations

Our experts behind the scenes

“An isolator is the most consistent answer for the most stringent quality requirements in parenteral filling. Mechanics, electrics and software must all be tuned perfectly to achieve the process performance for which Syntegon isolators are known today. The expectations of our customers motivates us to deliver maximum performance!”

Dr. Johannes Rauschnabel – Head of advanced development packaging technology and chief pharma expert

Our experts behind the scenes

“For the past 20-plus years and counting, I have associated Syntegon isolators with highest process reliability, the most stringent pharmaceutical requirements, and ultimately – the lives of millions of patients impacted worldwide.”

Mathias Kreher – Sales

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Our experts behind the scenes

“With Syntegon isolators I associate short and efficient cycle times for biodecontamination.”

Annika Klenk – Project manager cycle development/validation

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Our experts behind the scenes

“Working with Syntegon isolators and their cycle development requires close coordination with our customers. The interesting discussions that result from this are very valuable because they further develop us as well as our customers.”

Carmen Riedt – Group leader and responsible for qualification

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Our experts behind the scenes

“With Syntegon isolators, I associate a great collaboration, internally as well as with many different teams from our customers.”

Michael Meyer – Team leader cycle development/validationand process development

Our experts behind the scenes

„In line with our philosophy, the integration of air handling into filling line isolators is a major step in minimizing on-site complexity for our customers.
Our goal is to provide solutions that make our customers´ lives easier by reducing interfaces and maximizing integration.”

Lukas Munzinger - Global Product Manager Isolator Technology